Assay Detail
Binding
CHEMBL2214497
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Inhibition of PTP1B by para-nitrophenyl phosphate release assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.04 | 5.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2205895 | — | — | 1 | 5.79 |
| CHEMBL2205890 | — | — | 1 | 5.44 |
| CHEMBL129681 | — | — | 1 | 5.41 |
| CHEMBL2205896 | — | — | 1 | 5.39 |
| CHEMBL2205886 | — | — | 1 | 5.25 |
| CHEMBL2205888 | — | — | 1 | 5.06 |
| CHEMBL2205885 | — | — | 1 | 5.04 |
| CHEMBL2205894 | — | — | 1 | 5.04 |
| CHEMBL2205892 | — | — | 1 | 5.04 |
| CHEMBL2205884 | — | — | 1 | 5.03 |
| CHEMBL2205893 | — | — | 1 | 4.93 |
| CHEMBL1478 | LITHOCHOLIC ACID | — | 1 | 4.89 |
| CHEMBL2205898 | — | — | 1 | 4.88 |
| CHEMBL2205883 | — | — | 1 | 4.88 |
| CHEMBL2205897 | — | — | 1 | 4.72 |
| CHEMBL2205889 | — | — | 1 | 4.55 |
| CHEMBL2205887 | — | — | 1 | 4.40 |
| CHEMBL2205891 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2205895 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL2205890 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL129681 | — | IC50 | = | 3890.0 | nM | 5.41 |
| CHEMBL2205896 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL2205886 | — | IC50 | = | 5570.0 | nM | 5.25 |
| CHEMBL2205888 | — | IC50 | = | 8620.0 | nM | 5.06 |
| CHEMBL2205885 | — | IC50 | = | 9040.0 | nM | 5.04 |
| CHEMBL2205894 | — | IC50 | = | 9130.0 | nM | 5.04 |
| CHEMBL2205892 | — | IC50 | = | 9110.0 | nM | 5.04 |
| CHEMBL2205884 | — | IC50 | = | 9270.0 | nM | 5.03 |
| CHEMBL2205893 | — | IC50 | = | 11650.0 | nM | 4.93 |
| CHEMBL1478 | LITHOCHOLIC ACID | IC50 | = | 12740.0 | nM | 4.89 |
| CHEMBL2205898 | — | IC50 | = | 13210.0 | nM | 4.88 |
| CHEMBL2205883 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL2205897 | — | IC50 | = | 19164.0 | nM | 4.72 |
| CHEMBL2205889 | — | IC50 | = | 28220.0 | nM | 4.55 |
| CHEMBL2205887 | — | IC50 | = | 39440.0 | nM | 4.40 |
| CHEMBL2205891 | — | IC50 | > | 40000.0 | nM | - |