Assay Detail
Binding
CHEMBL2214787
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Inhibition of JAK2
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.99 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2208035 | — | — | 1 | 9.05 |
| CHEMBL2208032 | — | — | 1 | 8.77 |
| CHEMBL2208034 | — | — | 1 | 8.66 |
| CHEMBL2208033 | — | — | 1 | 8.57 |
| CHEMBL1077458 | — | — | 1 | 8.44 |
| CHEMBL2208025 | — | — | 1 | 8.38 |
| CHEMBL2208027 | — | — | 1 | 8.36 |
| CHEMBL2208028 | — | — | 1 | 8.29 |
| CHEMBL2207759 | — | — | 1 | 8.28 |
| CHEMBL2207758 | — | — | 1 | 8.24 |
| CHEMBL2208024 | — | — | 1 | 8.19 |
| CHEMBL2207766 | — | — | 1 | 8.16 |
| CHEMBL2208031 | — | — | 1 | 8.06 |
| CHEMBL2207760 | — | — | 1 | 8.04 |
| CHEMBL2207767 | — | — | 1 | 7.96 |
| CHEMBL2207764 | — | — | 1 | 7.90 |
| CHEMBL2208023 | — | — | 1 | 7.89 |
| CHEMBL2208029 | — | — | 1 | 7.40 |
| CHEMBL2207761 | — | — | 1 | 6.98 |
| CHEMBL2207765 | — | — | 1 | 6.89 |
| CHEMBL2207763 | — | — | 1 | 5.30 |
| CHEMBL2207762 | — | — | 1 | - |
| CHEMBL2208026 | — | — | 1 | - |
| CHEMBL2208030 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2208035 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL2208032 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL2208034 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2208033 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1077458 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL2208025 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL2208027 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL2208028 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL2207759 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL2207758 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL2208024 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL2207766 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL2208031 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL2207760 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL2207767 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL2207764 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL2208023 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL2208029 | — | IC50 | = | 39.6 | nM | 7.40 |
| CHEMBL2207761 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL2207765 | — | IC50 | = | 129.9 | nM | 6.89 |
| CHEMBL2207763 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2207762 | — | IC50 | > | 980.0 | nM | - |
| CHEMBL2208026 | — | IC50 | > | 980.0 | nM | - |
| CHEMBL2208030 | — | IC50 | > | 980.0 | nM | - |