Compound Detail
CHEMBL2207760
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2207760 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HKCCVEZCHYRSPJ-RUZDIDTESA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
472.6
MW (Da)
4.15
ALogP
7
HBA
2
HBD
82.6
PSA (Ų)
0.53
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK2 CHEMBL2971 | IC50 | 8.04 | 6.5133 | 9.1 | 3 |
| Tyrosine-protein kinase JAK3 CHEMBL2148 | IC50 | 6.25 | 6.25 | 557.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK2 | IC50 | = | 9.1 | nM | 8.04 | Inhibition of JAK2 | 23127890 |
| Tyrosine-protein kinase JAK3 | IC50 | = | 557.3 | nM | 6.25 | Inhibition of JAK3 | 23127890 |
| Tyrosine-protein kinase JAK2 | IC50 | = | 1431.3 | nM | 5.84 | Inhibition of JAK2 in HEL 92.1.7 cells assessed as inhibition of STAT1 phosphory... | 23127890 |
| Tyrosine-protein kinase JAK2 | IC50 | = | 2166.0 | nM | 5.66 | Inhibition of JAK2 in HEL 92.1.7 cells assessed as inhibition of STAT3 phosphory... | 23127890 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23127890 | 10.1016/j.bmcl.2012.10.007 | Tyrosine-protein kinase JAK2 | 3 |
| 23127890 | 10.1016/j.bmcl.2012.10.007 | Tyrosine-protein kinase JAK3 | 1 |
Data from ChEMBL 36 via Core Engine