Assay Detail
Binding
CHEMBL2214786
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Inhibition of JAK3
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.45 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2208035 | — | — | 1 | 7.21 |
| CHEMBL2208028 | — | — | 1 | 6.98 |
| CHEMBL2208033 | — | — | 1 | 6.80 |
| CHEMBL2208034 | — | — | 1 | 6.67 |
| CHEMBL2208031 | — | — | 1 | 6.53 |
| CHEMBL2208032 | — | — | 1 | 6.51 |
| CHEMBL2207758 | — | — | 1 | 6.43 |
| CHEMBL2207759 | — | — | 1 | 6.32 |
| CHEMBL2207760 | — | — | 1 | 6.25 |
| CHEMBL2208023 | — | — | 1 | 5.94 |
| CHEMBL2207763 | — | — | 1 | 5.30 |
| CHEMBL2208030 | — | — | 1 | - |
| CHEMBL2208029 | — | — | 1 | - |
| CHEMBL2208027 | — | — | 1 | - |
| CHEMBL2208026 | — | — | 1 | - |
| CHEMBL1077458 | — | — | 1 | - |
| CHEMBL2208025 | — | — | 1 | - |
| CHEMBL2208024 | — | — | 1 | - |
| CHEMBL2207767 | — | — | 1 | - |
| CHEMBL2207766 | — | — | 1 | - |
| CHEMBL2207765 | — | — | 1 | - |
| CHEMBL2207764 | — | — | 1 | - |
| CHEMBL2207761 | — | — | 1 | - |
| CHEMBL2207762 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2208035 | — | IC50 | = | 61.7 | nM | 7.21 |
| CHEMBL2208028 | — | IC50 | = | 104.5 | nM | 6.98 |
| CHEMBL2208033 | — | IC50 | = | 159.8 | nM | 6.80 |
| CHEMBL2208034 | — | IC50 | = | 214.2 | nM | 6.67 |
| CHEMBL2208031 | — | IC50 | = | 298.3 | nM | 6.53 |
| CHEMBL2208032 | — | IC50 | = | 306.8 | nM | 6.51 |
| CHEMBL2207758 | — | IC50 | = | 368.1 | nM | 6.43 |
| CHEMBL2207759 | — | IC50 | = | 483.8 | nM | 6.32 |
| CHEMBL2207760 | — | IC50 | = | 557.3 | nM | 6.25 |
| CHEMBL2208023 | — | IC50 | = | 1149.3 | nM | 5.94 |
| CHEMBL2207763 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2208030 | — | IC50 | > | 980.0 | nM | - |
| CHEMBL2208029 | — | IC50 | > | 980.0 | nM | - |
| CHEMBL2208027 | — | IC50 | > | 980.0 | nM | - |
| CHEMBL2208026 | — | IC50 | > | 980.0 | nM | - |
| CHEMBL1077458 | — | IC50 | > | 980.0 | nM | - |
| CHEMBL2208025 | — | IC50 | > | 980.0 | nM | - |
| CHEMBL2208024 | — | IC50 | > | 980.0 | nM | - |
| CHEMBL2207767 | — | IC50 | > | 980.0 | nM | - |
| CHEMBL2207766 | — | IC50 | > | 980.0 | nM | - |
| CHEMBL2207765 | — | IC50 | > | 980.0 | nM | - |
| CHEMBL2207764 | — | IC50 | > | 980.0 | nM | - |
| CHEMBL2207761 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2207762 | — | IC50 | > | 980.0 | nM | - |