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Assay Detail

CHEMBL2215079

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
ChEMBL ↗
44
Total Activities
22
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type COS-7
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

C-C chemokine receptor type 5 (CHEMBL274) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors.
Thiele S, Malmgaard-Clausen M, Engel-Andreasen J, Steen A, Rummel PC, Nielsen MC, Gloriam DE, Frimurer TM, Ulven T, Rosenkilde MM.
J Med Chem (2012) 55 : 8164 -8177
PubMed 22957890 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 4.46 5.10
pIC50 5 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2205805 — — 2 5.10
CHEMBL89445 TERPYRIDINE — 2 4.60
CHEMBL375781 NEOCUPROINE — 2 4.52
CHEMBL415879 PHENANTHROLINE — 2 4.30
CHEMBL316589 — — 2 4.20
CHEMBL39879 DIPYRIDYL — 2 4.10
CHEMBL2205804 — — 2 -
CHEMBL1976682 — — 2 -
CHEMBL2205803 — — 2 -
CHEMBL2205802 — — 2 -
CHEMBL2205801 — — 2 -
CHEMBL1623498 — — 2 -
CHEMBL317115 — — 2 -
CHEMBL98682 — — 2 -
CHEMBL99384 — — 2 -
CHEMBL593442 — — 2 -
CHEMBL2205809 — — 2 -
CHEMBL2205808 — — 2 -
CHEMBL101165 — — 2 -
CHEMBL2205807 ABAMETAPIR 4.0 2 -
CHEMBL2205806 — — 2 -
CHEMBL2205810 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2205805 — IC50 = 7943.28 nM 5.10
CHEMBL2205805 — IC50 = 8100.0 nM 5.09
CHEMBL89445 TERPYRIDINE IC50 = 25118.86 nM 4.60
CHEMBL89445 TERPYRIDINE IC50 = 25000.0 nM 4.60
CHEMBL375781 NEOCUPROINE IC50 = 30000.0 nM 4.52
CHEMBL375781 NEOCUPROINE IC50 = 31622.78 nM 4.50
CHEMBL415879 PHENANTHROLINE IC50 = 50118.72 nM 4.30
CHEMBL415879 PHENANTHROLINE IC50 = 53000.0 nM 4.28
CHEMBL316589 — IC50 = 63095.73 nM 4.20
CHEMBL316589 — IC50 = 66000.0 nM 4.18
CHEMBL39879 DIPYRIDYL IC50 = 79432.82 nM 4.10
CHEMBL39879 DIPYRIDYL IC50 = 84000.0 nM 4.08
CHEMBL99384 — pIC50 - — -
CHEMBL593442 — IC50 = 316227.77 nM -
CHEMBL2205802 — IC50 = 587000.0 nM -
CHEMBL2205803 — IC50 = 128000.0 nM -
CHEMBL1976682 — IC50 = 205000.0 nM -
CHEMBL2205801 — IC50 < 1000000.0 nM -
CHEMBL2205804 — IC50 = 519000.0 nM -
CHEMBL1623498 — IC50 < 1000000.0 nM -
CHEMBL317115 — pIC50 - — -
CHEMBL98682 — pIC50 - — -
CHEMBL2205806 — IC50 = 501187.23 nM -
CHEMBL2205807 ABAMETAPIR IC50 = 199526.23 nM -
CHEMBL101165 — IC50 = 316227.77 nM -
CHEMBL2205808 — IC50 = 1584893.19 nM -
CHEMBL2205810 — pIC50 - — -
CHEMBL2205809 — pIC50 - — -
CHEMBL1623498 — IC50 > 1000000.0 nM -
CHEMBL317115 — IC50 - — -
CHEMBL98682 — IC50 - — -
CHEMBL2205802 — IC50 = 630957.34 nM -
CHEMBL2205810 — IC50 - — -
CHEMBL99384 — IC50 - — -
CHEMBL593442 — IC50 = 300000.0 nM -
CHEMBL2205809 — IC50 - — -
CHEMBL2205803 — IC50 = 125892.54 nM -
CHEMBL2205808 — IC50 = 1511000.0 nM -
CHEMBL101165 — IC50 = 337000.0 nM -
CHEMBL2205807 ABAMETAPIR IC50 = 206000.0 nM -
CHEMBL2205806 — IC50 = 511000.0 nM -
CHEMBL1976682 — IC50 = 199526.23 nM -
CHEMBL2205804 — IC50 = 501187.23 nM -
CHEMBL2205801 — IC50 > 1000000.0 nM -