Assay Detail
Binding
CHEMBL2215171
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Inhibition of ribosome-mediated protein synthesis in rabbit reticulocytes after 60 mins by coupled transcription/translation assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Subcellular | Ribosome |
| Confidence | 2 — Organism |
| Curated By | Autocuration |
Publication
Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.11 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2206184 | — | — | 1 | 6.16 |
| CHEMBL2206185 | — | — | 1 | 6.05 |
| CHEMBL2206194 | — | — | 1 | 5.82 |
| CHEMBL2206186 | GENETICIN SULFATE SALT | — | 1 | 5.70 |
| CHEMBL2206189 | — | — | 1 | 5.55 |
| CHEMBL2206193 | — | — | 1 | 5.34 |
| CHEMBL2206192 | — | — | 1 | 5.28 |
| CHEMBL2206195 | — | — | 1 | 5.10 |
| CHEMBL2206190 | — | — | 1 | 4.80 |
| CHEMBL2206188 | — | — | 1 | 4.77 |
| CHEMBL2206187 | — | — | 1 | 4.62 |
| CHEMBL2206191 | — | — | 1 | 4.55 |
| CHEMBL373500 | — | — | 1 | 4.51 |
| CHEMBL2206196 | PAROMOMYCIN SULFATE | 4.0 | 1 | 4.24 |
| CHEMBL6067484 | GENTAMICIN SULFATE | 4.0 | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2206184 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2206185 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2206194 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2206186 | GENETICIN SULFATE SALT | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2206189 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2206193 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL2206192 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL2206195 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2206190 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL2206188 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2206187 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL2206191 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL373500 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL2206196 | PAROMOMYCIN SULFATE | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL6067484 | GENTAMICIN SULFATE | IC50 | = | 62000.0 | nM | 4.21 |