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Compound Detail

CHEMBL2206196

PAROMOMYCIN SULFATE
💊 Approved Drug
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💊 Approved Drug
NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O.O=S(=O)(O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL2206196
Name PAROMOMYCIN SULFATE
Phase Approved
Structure Type MOL
InChI Key LJRDOKAZOAKLDU-UDXJMMFXSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL370143
Active Moiety CHEMBL370143

Known Names

Aminosidine Aminoxidin Farmiglucin Farminosidin Gabbromicina Gabbromycin Gabbroral Humagel Humatin NSC-758421 Paramicina Pargonyl +3 more
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
20
Publications
15
Known Names
5
Indications
1
Mechanisms

Molecular Properties

615.6
MW (Da)
-8.86
ALogP
19
HBA
13
HBD
347.3
PSA (Ų)
0.11
QED
3
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1969
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Oral

Flags

Natural Product
USAN Stem -mycin

Extended Properties

Molecular Formula C23H47N5O18S
MW 713.71
Aromatic Rings 0
Heavy Atoms 42
NP-Likeness 1.16

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Bacterial 70S ribosome inhibitor INHIBITOR Bacterial 70S ribosome ✓ ✓

Indications

Amebiasis Infections Leishmaniasis Leishmaniasis, Visceral Osteomyelitis

Activity Summary

IC50 4 meas. best 7.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
 IC50 7.3 7.3 50.0 1
Ribosome
CHEMBL613299
 IC50 7.29 5.2567 51.0 3

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 50.0 nM 7.3 Inhibition of ribosome S30 subunit-mediated protein synthesis in Escherichia col... 23148581
Ribosome IC50 = 51.0 nM 7.29 Inhibition of ribosome-mediated translation in prokaryotic system -
Ribosome IC50 = 57000.0 nM 4.24 Inhibition of ribosome-mediated protein synthesis in rabbit reticulocytes after ... 23148581
Ribosome IC50 = 57000.0 nM 4.24 Inhibition of ribosome-mediated translation in eukaryotic system -

Literature References

PubMed DOI Target Context # Activities
16997553 10.1016/j.bmcl.2006.09.013 Protocadherin-15 4
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
16997553 10.1016/j.bmcl.2006.09.013 Escherichia coli 2
- 10.1039/C0MD00195C Ribosome 2
23148581 10.1021/jm3012992 Unchecked 2
16997553 10.1016/j.bmcl.2006.09.013 Bacillus subtilis 2
20843939 10.1124/dmd.110.035113 Hepatotoxicity 1
20553011 10.1021/tx1000865 Hepatotoxicity 1
23148581 10.1021/jm3012992 80S Ribosome 1
23148581 10.1021/jm3012992 Ribosome 1
23148581 10.1021/jm3012992 Escherichia coli 1
23148581 10.1021/jm3012992 HEK293 1
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B1 1
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B3 1
- 10.1039/C0MD00195C HEK293 1
- 10.1039/C0MD00195C HFF 1
17417631 10.1038/nchembio873 Unchecked 1
- 10.1039/C0MD00195C Bacillus spizizenii 1
- 10.21203/rs.3.rs-23951/v1 SARS-CoV-2 1
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 1

Data from ChEMBL 36 via Core Engine