Assay Detail
Binding
CHEMBL2215172
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Inhibition of ribosome S30 subunit-mediated protein synthesis in Escherichia coli after 60 mins by coupled transcription/translation assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.27 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2206186 | GENETICIN SULFATE SALT | — | 1 | 8.00 |
| CHEMBL6067484 | GENTAMICIN SULFATE | 4.0 | 1 | 7.52 |
| CHEMBL2206196 | PAROMOMYCIN SULFATE | 4.0 | 1 | 7.30 |
| CHEMBL2206187 | — | — | 1 | 6.70 |
| CHEMBL373500 | — | — | 1 | 6.30 |
| CHEMBL2206193 | — | — | 1 | 6.10 |
| CHEMBL2206189 | — | — | 1 | 6.00 |
| CHEMBL2206194 | — | — | 1 | 5.96 |
| CHEMBL2206188 | — | — | 1 | 5.96 |
| CHEMBL2206185 | — | — | 1 | 5.75 |
| CHEMBL2206184 | — | — | 1 | 5.75 |
| CHEMBL2206195 | — | — | 1 | 5.72 |
| CHEMBL2206190 | — | — | 1 | 5.70 |
| CHEMBL2206191 | — | — | 1 | 5.68 |
| CHEMBL2206192 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2206186 | GENETICIN SULFATE SALT | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL6067484 | GENTAMICIN SULFATE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2206196 | PAROMOMYCIN SULFATE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2206187 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL373500 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2206193 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2206189 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2206194 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2206188 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2206185 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2206184 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2206195 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2206190 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2206191 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2206192 | — | IC50 | = | 2300.0 | nM | 5.64 |