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Assay Detail

CHEMBL2215558

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Binding
Binding affinity to kappa opioid receptor
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Kappa-type opioid receptor (CHEMBL237)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A σ(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).
Banister SD, Manoli M, Doddareddy MR, Hibbs DE, Kassiou M.
Bioorg Med Chem Lett (2012) 22 : 6053 -6058
PubMed 22959245 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 27 5.91 6.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1189234 1 6.31
CHEMBL2205825 1 6.21
CHEMBL2205836 1 5.96
CHEMBL2205823 1 5.96
CHEMBL2205827 1 5.94
CHEMBL2205811 1 5.85
CHEMBL2205829 1 5.85
CHEMBL2205812 1 5.80
CHEMBL2205813 1 5.68
CHEMBL2205832 1 5.57
CHEMBL2205815 1 -
CHEMBL2205835 1 -
CHEMBL2205834 1 -
CHEMBL2205831 1 -
CHEMBL2205830 1 -
CHEMBL2205828 1 -
CHEMBL2205826 1 -
CHEMBL1779060 1 -
CHEMBL1779059 1 -
CHEMBL2205818 1 -
CHEMBL2205820 1 -
CHEMBL2205821 1 -
CHEMBL2205819 1 -
CHEMBL608560 1 -
CHEMBL602850 1 -
CHEMBL1779058 1 -
CHEMBL2205822 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1189234 Ki = 488.0 nM 6.31
CHEMBL2205825 Ki = 617.0 nM 6.21
CHEMBL2205836 Ki = 1107.0 nM 5.96
CHEMBL2205823 Ki = 1094.0 nM 5.96
CHEMBL2205827 Ki = 1147.0 nM 5.94
CHEMBL2205811 Ki = 1420.0 nM 5.85
CHEMBL2205829 Ki = 1426.0 nM 5.85
CHEMBL2205812 Ki = 1575.0 nM 5.80
CHEMBL2205813 Ki = 2080.0 nM 5.68
CHEMBL2205832 Ki = 2688.0 nM 5.57
CHEMBL2205815 Ki - -
CHEMBL2205835 Ki - -
CHEMBL2205834 Ki - -
CHEMBL2205831 Ki - -
CHEMBL2205830 Ki - -
CHEMBL2205828 Ki - -
CHEMBL2205826 Ki - -
CHEMBL1779060 Ki - -
CHEMBL1779059 Ki - -
CHEMBL2205818 Ki - -
CHEMBL2205820 Ki - -
CHEMBL2205821 Ki - -
CHEMBL2205819 Ki - -
CHEMBL608560 Ki - -
CHEMBL602850 Ki - -
CHEMBL1779058 Ki - -
CHEMBL2205822 Ki - -