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Compound Detail

CHEMBL2205832

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OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccn1

Basic Information

ChEMBL ID CHEMBL2205832
Phase Preclinical
Structure Type MOL
InChI Key ZUHLFYHHSNMSRE-UHFFFAOYSA-N
7
Targets
7
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names

Molecular Properties

266.3
MW (Da)
1.34
ALogP
3
HBA
1
HBD
36.4
PSA (Ų)
0.88
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H18N2O
MW 266.34
Aromatic Rings 1
Heavy Atoms 20
NP-Likeness 0.14

Activity Summary

Ki 7 meas. best 7.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Ki 7.7 7.7 20.0 1
Sigma non-opioid intracellular receptor 1
CHEMBL3602
Ki 5.98 5.98 1048.0 1
Kappa-type opioid receptor
CHEMBL237
Ki 5.57 5.57 2688.0 1
Mu-type opioid receptor
CHEMBL233
Ki 5.47 5.47 3415.0 1
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 5.3 5.3 5011.0 1
Delta-type opioid receptor
CHEMBL236
Ki 5.29 5.29 5168.0 1
Muscarinic acetylcholine receptor M4
CHEMBL1821
Ki 5.09 5.09 8135.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22959245 10.1016/j.bmcl.2012.08.046 Unchecked 5
22959245 10.1016/j.bmcl.2012.08.046 Sodium-dependent noradrenaline transporter 1
22959245 10.1016/j.bmcl.2012.08.046 Sigma non-opioid intracellular receptor 1 1
22959245 10.1016/j.bmcl.2012.08.046 Muscarinic acetylcholine receptor M1 1
22959245 10.1016/j.bmcl.2012.08.046 Muscarinic acetylcholine receptor M3 1
22959245 10.1016/j.bmcl.2012.08.046 Muscarinic acetylcholine receptor M5 1
22959245 10.1016/j.bmcl.2012.08.046 Alpha-1D adrenergic receptor 1
22959245 10.1016/j.bmcl.2012.08.046 D(3) dopamine receptor 1
22959245 10.1016/j.bmcl.2012.08.046 5-hydroxytryptamine receptor 1A 1
22959245 10.1016/j.bmcl.2012.08.046 5-hydroxytryptamine receptor 1D 1
22959245 10.1016/j.bmcl.2012.08.046 Alpha-1A adrenergic receptor 1
22959245 10.1016/j.bmcl.2012.08.046 Alpha-2C adrenergic receptor 1
22959245 10.1016/j.bmcl.2012.08.046 Delta-type opioid receptor 1
22959245 10.1016/j.bmcl.2012.08.046 Alpha-2B adrenergic receptor 1
22959245 10.1016/j.bmcl.2012.08.046 Histamine H2 receptor 1
22959245 10.1016/j.bmcl.2012.08.046 Muscarinic acetylcholine receptor M2 1
22959245 10.1016/j.bmcl.2012.08.046 Muscarinic acetylcholine receptor M4 1
22959245 10.1016/j.bmcl.2012.08.046 Kappa-type opioid receptor 1
22959245 10.1016/j.bmcl.2012.08.046 Mu-type opioid receptor 1
22959245 10.1016/j.bmcl.2012.08.046 Sodium-dependent dopamine transporter 1

Data from ChEMBL 36 via Core Engine