Assay Detail
Binding
CHEMBL2215100
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Displacement of [3H]DTG from rat PC12 cells sigma 2 receptor
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | PC-12 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A σ(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 7.29 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2205831 | — | — | 1 | 8.66 |
| CHEMBL143950 | — | — | 1 | 8.31 |
| CHEMBL2205820 | — | — | 1 | 8.20 |
| CHEMBL2205822 | — | — | 1 | 8.05 |
| CHEMBL1189234 | — | — | 1 | 7.92 |
| CHEMBL2205827 | — | — | 1 | 7.90 |
| CHEMBL2205832 | — | — | 1 | 7.70 |
| CHEMBL2205819 | — | — | 1 | 7.58 |
| CHEMBL2205816 | — | — | 1 | 7.57 |
| CHEMBL2205824 | — | — | 1 | 7.57 |
| CHEMBL2205823 | — | — | 1 | 7.56 |
| CHEMBL2205825 | — | — | 1 | 7.56 |
| CHEMBL2205821 | — | — | 1 | 7.27 |
| CHEMBL2205812 | — | — | 1 | 7.25 |
| CHEMBL2205836 | — | — | 1 | 7.25 |
| CHEMBL2205835 | — | — | 1 | 7.17 |
| CHEMBL2205826 | — | — | 1 | 7.11 |
| CHEMBL2205815 | — | — | 1 | 7.01 |
| CHEMBL2205811 | — | — | 1 | 7.00 |
| CHEMBL2205817 | — | — | 1 | 7.00 |
| CHEMBL2205813 | — | — | 1 | 6.97 |
| CHEMBL2205828 | — | — | 1 | 6.90 |
| CHEMBL2205829 | — | — | 1 | 6.59 |
| CHEMBL2205814 | — | — | 1 | 6.59 |
| CHEMBL2205818 | — | — | 1 | 6.39 |
| CHEMBL2205834 | — | — | 1 | 6.29 |
| CHEMBL2205833 | — | — | 1 | 5.49 |
| CHEMBL2205830 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2205831 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL143950 | — | Ki | = | 4.91 | nM | 8.31 |
| CHEMBL2205820 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL2205822 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL1189234 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL2205827 | — | Ki | = | 12.6 | nM | 7.90 |
| CHEMBL2205832 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL2205819 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL2205816 | — | Ki | = | 26.8 | nM | 7.57 |
| CHEMBL2205824 | — | Ki | = | 26.8 | nM | 7.57 |
| CHEMBL2205823 | — | Ki | = | 27.3 | nM | 7.56 |
| CHEMBL2205825 | — | Ki | = | 27.3 | nM | 7.56 |
| CHEMBL2205821 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL2205812 | — | Ki | = | 56.9 | nM | 7.25 |
| CHEMBL2205836 | — | Ki | = | 56.9 | nM | 7.25 |
| CHEMBL2205835 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL2205826 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL2205815 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL2205811 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2205817 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2205813 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL2205828 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL2205829 | — | Ki | = | 259.0 | nM | 6.59 |
| CHEMBL2205814 | — | Ki | = | 259.0 | nM | 6.59 |
| CHEMBL2205818 | — | Ki | = | 404.0 | nM | 6.39 |
| CHEMBL2205834 | — | Ki | = | 514.0 | nM | 6.29 |
| CHEMBL2205833 | — | Ki | = | 3234.0 | nM | 5.49 |
| CHEMBL2205830 | — | Ki | > | 10000.0 | nM | - |