Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL2205833

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
OC12C3C4CC5C6C4C1C6C(C53)N2Cc1cccnc1

Basic Information

ChEMBL ID CHEMBL2205833
Phase Preclinical
Structure Type MOL
InChI Key DCGVCGVBZDMLGR-UHFFFAOYSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names

Molecular Properties

266.3
MW (Da)
1.34
ALogP
3
HBA
1
HBD
36.4
PSA (Ų)
0.88
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H18N2O
MW 266.34
Aromatic Rings 1
Heavy Atoms 20
NP-Likeness 0.41

Activity Summary

Ki 3 meas. best 5.49

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Ki 5.49 5.49 3234.0 2
Alpha-2C adrenergic receptor
CHEMBL1916
Ki 5.33 5.33 4732.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23981939 10.1016/j.bmc.2013.07.045 Unchecked 5
22959245 10.1016/j.bmcl.2012.08.046 Unchecked 5
22959245 10.1016/j.bmcl.2012.08.046 Alpha-1D adrenergic receptor 1
23981939 10.1016/j.bmc.2013.07.045 Muscarinic acetylcholine receptor M3 1
22959245 10.1016/j.bmcl.2012.08.046 5-hydroxytryptamine receptor 7 1
22959245 10.1016/j.bmcl.2012.08.046 Sodium-dependent serotonin transporter 1
22959245 10.1016/j.bmcl.2012.08.046 Muscarinic acetylcholine receptor M1 1
22959245 10.1016/j.bmcl.2012.08.046 Muscarinic acetylcholine receptor M3 1
22959245 10.1016/j.bmcl.2012.08.046 Muscarinic acetylcholine receptor M4 1
22959245 10.1016/j.bmcl.2012.08.046 Muscarinic acetylcholine receptor M5 1
22959245 10.1016/j.bmcl.2012.08.046 Delta-type opioid receptor 1
22959245 10.1016/j.bmcl.2012.08.046 Kappa-type opioid receptor 1
22959245 10.1016/j.bmcl.2012.08.046 D(3) dopamine receptor 1
22959245 10.1016/j.bmcl.2012.08.046 5-hydroxytryptamine receptor 1A 1
22959245 10.1016/j.bmcl.2012.08.046 5-hydroxytryptamine receptor 1D 1
22959245 10.1016/j.bmcl.2012.08.046 Alpha-1A adrenergic receptor 1
22959245 10.1016/j.bmcl.2012.08.046 Sodium-dependent noradrenaline transporter 1
22959245 10.1016/j.bmcl.2012.08.046 Mu-type opioid receptor 1
22959245 10.1016/j.bmcl.2012.08.046 Alpha-2B adrenergic receptor 1
22959245 10.1016/j.bmcl.2012.08.046 Alpha-2C adrenergic receptor 1

Data from ChEMBL 36 via Core Engine