Assay Detail
Binding
CHEMBL2215570
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to M4 muscarinic receptor
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M4 (CHEMBL1821) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A σ(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 5.90 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2205812 | — | — | 1 | 6.33 |
| CHEMBL2205823 | — | — | 1 | 6.29 |
| CHEMBL2205825 | — | — | 1 | 6.18 |
| CHEMBL2205836 | — | — | 1 | 6.16 |
| CHEMBL2205811 | — | — | 1 | 6.01 |
| CHEMBL2205817 | — | — | 1 | 5.95 |
| CHEMBL2205827 | — | — | 1 | 5.91 |
| CHEMBL2205829 | — | — | 1 | 5.88 |
| CHEMBL1189234 | — | — | 1 | 5.85 |
| CHEMBL2205813 | — | — | 1 | 5.63 |
| CHEMBL2205816 | — | — | 1 | 5.53 |
| CHEMBL2205832 | — | — | 1 | 5.09 |
| CHEMBL2205835 | — | — | 1 | - |
| CHEMBL2205818 | — | — | 1 | - |
| CHEMBL2205815 | — | — | 1 | - |
| CHEMBL2205830 | — | — | 1 | - |
| CHEMBL2205828 | — | — | 1 | - |
| CHEMBL2205826 | — | — | 1 | - |
| CHEMBL1779060 | — | — | 1 | - |
| CHEMBL1779059 | — | — | 1 | - |
| CHEMBL1779058 | — | — | 1 | - |
| CHEMBL602850 | — | — | 1 | - |
| CHEMBL2205831 | — | — | 1 | - |
| CHEMBL2205820 | — | — | 1 | - |
| CHEMBL2205821 | — | — | 1 | - |
| CHEMBL2205819 | — | — | 1 | - |
| CHEMBL2205834 | — | — | 1 | - |
| CHEMBL608560 | — | — | 1 | - |
| CHEMBL2205822 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2205812 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL2205823 | — | Ki | = | 514.0 | nM | 6.29 |
| CHEMBL2205825 | — | Ki | = | 659.0 | nM | 6.18 |
| CHEMBL2205836 | — | Ki | = | 685.0 | nM | 6.16 |
| CHEMBL2205811 | — | Ki | = | 977.0 | nM | 6.01 |
| CHEMBL2205817 | — | Ki | = | 1118.0 | nM | 5.95 |
| CHEMBL2205827 | — | Ki | = | 1233.0 | nM | 5.91 |
| CHEMBL2205829 | — | Ki | = | 1302.0 | nM | 5.88 |
| CHEMBL1189234 | — | Ki | = | 1415.0 | nM | 5.85 |
| CHEMBL2205813 | — | Ki | = | 2338.0 | nM | 5.63 |
| CHEMBL2205816 | — | Ki | = | 2961.0 | nM | 5.53 |
| CHEMBL2205832 | — | Ki | = | 8135.0 | nM | 5.09 |
| CHEMBL2205835 | — | Ki | - | — | - | |
| CHEMBL2205818 | — | Ki | - | — | - | |
| CHEMBL2205815 | — | Ki | - | — | - | |
| CHEMBL2205830 | — | Ki | - | — | - | |
| CHEMBL2205828 | — | Ki | - | — | - | |
| CHEMBL2205826 | — | Ki | - | — | - | |
| CHEMBL1779060 | — | Ki | - | — | - | |
| CHEMBL1779059 | — | Ki | - | — | - | |
| CHEMBL1779058 | — | Ki | - | — | - | |
| CHEMBL602850 | — | Ki | - | — | - | |
| CHEMBL2205831 | — | Ki | - | — | - | |
| CHEMBL2205820 | — | Ki | - | — | - | |
| CHEMBL2205821 | — | Ki | - | — | - | |
| CHEMBL2205819 | — | Ki | - | — | - | |
| CHEMBL2205834 | — | Ki | - | — | - | |
| CHEMBL608560 | — | Ki | - | — | - | |
| CHEMBL2205822 | — | Ki | - | — | - |