Assay Detail
Binding
CHEMBL2215698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of bovine pancreatic RNase A type 12-A assessed as degradation of yeast tRNA preincubated for 10 mins before addition of the enzyme by double reciprocal plot analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 4.53 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2206660 | — | — | 1 | 5.80 |
| CHEMBL2206117 | — | — | 1 | 4.59 |
| CHEMBL100259 | URIDINE | 3.0 | 1 | 4.54 |
| CHEMBL2206657 | — | — | 1 | 4.51 |
| CHEMBL54918 | 5-FLUOROURIDINE | 2.0 | 1 | 4.47 |
| CHEMBL106175 | — | — | 1 | 4.36 |
| CHEMBL2206659 | — | — | 1 | 4.35 |
| CHEMBL2206658 | — | — | 1 | 4.16 |
| CHEMBL2206656 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2206660 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL2206117 | — | Ki | = | 25800.0 | nM | 4.59 |
| CHEMBL100259 | URIDINE | Ki | = | 28500.0 | nM | 4.54 |
| CHEMBL2206657 | — | Ki | = | 30800.0 | nM | 4.51 |
| CHEMBL54918 | 5-FLUOROURIDINE | Ki | = | 33600.0 | nM | 4.47 |
| CHEMBL106175 | — | Ki | = | 44100.0 | nM | 4.36 |
| CHEMBL2206659 | — | Ki | = | 44500.0 | nM | 4.35 |
| CHEMBL2206658 | — | Ki | = | 69100.0 | nM | 4.16 |
| CHEMBL2206656 | — | Ki | = | 94800.0 | nM | 4.02 |