Compound Detail
CHEMBL100259
URIDINE 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL100259 |
| Name | URIDINE |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | DRTQHJPVMGBUCF-XVFCMESISA-N |
6
Targets
18
Activities
3
Assay Types
1
PK Parameters
20
Publications
4
Known Names
6
Indications
Molecular Properties
244.2
MW (Da)
-2.85
ALogP
7
HBA
4
HBD
124.8
PSA (Ų)
0.44
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Cataract Lung Neoplasms Bipolar Disorder Keratoconus Prognathism Carcinoma, Non-Small-Cell Lung
Activity Summary
IC50 9 meas. best 5.27
Ki 8 meas. best 5.47
EC50 1 meas. best 4.18
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Solute carrier family 28 member 3 CHEMBL5707 | Ki | 5.47 | 5.47 | 3400.0 | 1 |
| Sodium/nucleoside cotransporter 1 CHEMBL5551 | Ki | 5.28 | 5.28 | 5200.0 | 1 |
| Solute carrier family 28 member 3 CHEMBL5707 | IC50 | 5.27 | 5.27 | 5400.0 | 1 |
| Sodium/nucleoside cotransporter 1 CHEMBL5551 | IC50 | 5.24 | 5.24 | 5800.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 4.54 | 4.54 | 28500.0 | 1 |
| Sodium/nucleoside cotransporter 2 CHEMBL5780 | Ki | 4.51 | 4.51 | 31000.0 | 1 |
| Sodium/nucleoside cotransporter 2 CHEMBL5780 | IC50 | 4.5 | 4.5 | 32000.0 | 1 |
| Equilibrative nucleoside transporter 1 CHEMBL1997 | Ki | 4.29 | 4.29 | 51000.0 | 1 |
| Equilibrative nucleoside transporter 1 CHEMBL1997 | IC50 | 4.28 | 4.28 | 52000.0 | 1 |
| Hepatitis C virus CHEMBL379 | EC50 | 4.18 | 4.18 | 65900.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.03333 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine