Assay Detail
Binding
CHEMBL2215842
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]5-carboxamidotryptamine to human 5HT1A expressed in HEK293 cells by filter binding assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 6.76 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2205051 | — | — | 1 | 7.85 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.68 |
| CHEMBL2205041 | — | — | 1 | 7.52 |
| CHEMBL2204357 | — | — | 1 | 7.51 |
| CHEMBL2204360 | — | — | 1 | 7.41 |
| CHEMBL2205044 | — | — | 1 | 7.41 |
| CHEMBL2205045 | — | — | 1 | 7.36 |
| CHEMBL2205054 | — | — | 1 | 7.28 |
| CHEMBL2205050 | — | — | 1 | 7.23 |
| CHEMBL2205035 | — | — | 1 | 7.19 |
| CHEMBL2204355 | — | — | 1 | 7.17 |
| CHEMBL2205053 | — | — | 1 | 7.17 |
| CHEMBL2205043 | — | — | 1 | 7.16 |
| CHEMBL2204356 | — | — | 1 | 7.12 |
| CHEMBL2204363 | — | — | 1 | 7.11 |
| CHEMBL2204359 | — | — | 1 | 7.11 |
| CHEMBL2204361 | — | — | 1 | 7.03 |
| CHEMBL2205049 | — | — | 1 | 7.00 |
| CHEMBL2205033 | — | — | 1 | 6.92 |
| CHEMBL2205042 | — | — | 1 | 6.89 |
| CHEMBL2205048 | — | — | 1 | 6.85 |
| CHEMBL2205052 | — | — | 1 | 6.80 |
| CHEMBL2204362 | — | — | 1 | 6.68 |
| CHEMBL2205046 | — | — | 1 | 6.62 |
| CHEMBL2205034 | — | — | 1 | 6.51 |
| CHEMBL2204358 | — | — | 1 | 6.48 |
| CHEMBL2204364 | — | — | 1 | 6.38 |
| CHEMBL2205032 | — | — | 1 | 6.27 |
| CHEMBL2205039 | — | — | 1 | 5.96 |
| CHEMBL2205036 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2205051 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL49 | BUSPIRONE | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL2205041 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL2204357 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL2204360 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL2205044 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL2205045 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL2205054 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL2205050 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL2205035 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL2205053 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL2204355 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL2205043 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL2204356 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL2204359 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL2204363 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL2204361 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL2205049 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2205033 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL2205042 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL2205048 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL2205052 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL2204362 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL2205046 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL2205034 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL2204358 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL2204364 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL2205032 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL2205036 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL2205039 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL2205031 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL2205047 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL2205038 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL2204365 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL2205040 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL2205037 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL549 | CITALOPRAM | Ki | - | — | - | |
| CHEMBL46 | ONDANSETRON | Ki | - | — | - |