Assay Detail
Functional
CHEMBL2216082
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Antiproliferative activity against human HaCaT cells assessed as cell viability by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HaCaT |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel heterocyclic derivatives of combretastatin A-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.24 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 9.00 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.92 |
| CHEMBL2205254 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL107 | COLCHICINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2205254 | — | IC50 | = | 16.0 | nM | 7.80 |