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Assay Detail

CHEMBL2216251

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity against progesterone receptor in human T47D cells by alkaline phosphatase assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type T47D
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Progesterone receptor (CHEMBL208)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel progesterone receptor modulators: 4-aryl-phenylsulfonamides.
McComas C, Cohen J, Huselton C, Marella M, Melenski E, Mugford C, Slayden O, Winneker R, Wrobel J, Yudt MR, Fensome A.
Bioorg Med Chem Lett (2012) 22 : 7119 -7122
PubMed 23079530 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 7.73 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267431 ASOPRISNIL 3.0 1 9.52
CHEMBL2203825 1 8.82
CHEMBL2203832 1 8.22
CHEMBL2203819 1 8.10
CHEMBL2203833 1 8.10
CHEMBL2203821 1 8.05
CHEMBL2203823 1 8.00
CHEMBL2203836 1 7.92
CHEMBL2203834 1 7.92
CHEMBL2203829 1 7.52
CHEMBL2203830 1 7.44
CHEMBL2203826 1 7.24
CHEMBL2203837 1 7.24
CHEMBL2203820 1 7.12
CHEMBL2203818 1 7.12
CHEMBL2203822 1 7.11
CHEMBL2203835 1 6.89
CHEMBL2203824 1 6.78
CHEMBL2203831 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267431 ASOPRISNIL IC50 = 0.3 nM 9.52
CHEMBL2203825 IC50 = 1.5 nM 8.82
CHEMBL2203832 IC50 = 6.0 nM 8.22
CHEMBL2203819 IC50 = 8.0 nM 8.10
CHEMBL2203833 IC50 = 8.0 nM 8.10
CHEMBL2203821 IC50 = 9.0 nM 8.05
CHEMBL2203823 IC50 = 10.0 nM 8.00
CHEMBL2203836 IC50 = 12.0 nM 7.92
CHEMBL2203834 IC50 = 12.0 nM 7.92
CHEMBL2203829 IC50 = 30.0 nM 7.52
CHEMBL2203830 IC50 = 36.0 nM 7.44
CHEMBL2203826 IC50 = 58.0 nM 7.24
CHEMBL2203837 IC50 = 57.0 nM 7.24
CHEMBL2203820 IC50 = 76.0 nM 7.12
CHEMBL2203818 IC50 = 75.0 nM 7.12
CHEMBL2203822 IC50 = 78.0 nM 7.11
CHEMBL2203835 IC50 = 128.0 nM 6.89
CHEMBL2203824 IC50 = 167.0 nM 6.78
CHEMBL2203831 IC50 > 3000.0 nM -