Assay Detail
Binding
CHEMBL2216973
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of carnitine palmitoyltransferase in Sprague-Dawley rat liver mitochondria assessed as formation of palmitoyl[3H]carnitine from palmitoyl-CoA and [3H]carnitine pre-incubated for 5 mins
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Mitochondria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.45 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2216797 | — | — | 1 | 7.58 |
| CHEMBL2216798 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2216797 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2216798 | — | IC50 | = | 48.0 | nM | 7.32 |