Compound Detail
CHEMBL2216797
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CCCCCCCCCCCCCCC1(C(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]2O[C@@H](n3cnc4c(N)cnnc43)[C@H](O)[C@@H]2OP(=O)(O)O)CO1
Basic Information
| ChEMBL ID | CHEMBL2216797 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FYLVQWVZDSAKSJ-YDIQEVTHSA-N |
1
Targets
5
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1034.0
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 7.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.58 | 6.22 | 26.0 | 5 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 26.0 | nM | 7.58 | Inhibition of carnitine palmitoyltransferase in Sprague-Dawley rat liver mitocho... | 21504156 |
| Unchecked | IC50 | = | 60.0 | nM | 7.22 | Inhibition of carnitine palmitoyltransferase in rat liver mitochondria using [14... | 21504156 |
| Unchecked | IC50 | = | 500.0 | nM | 6.3 | Inhibition of carnitine palmitoyltransferase in rat muscle using [14C]carnitine ... | 21504156 |
| Unchecked | IC50 | = | 10000.0 | nM | 5.0 | Inhibition of carnitine palmitoyltransferase in rat liver mitochondria assessed ... | 21504156 |
| Unchecked | IC50 | = | 10000.0 | nM | 5.0 | Inhibition of carnitine palmitoyltransferase in rat liver mitochondria assessed ... | 21504156 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21504156 | 10.1021/jm100809g | Unchecked | 5 |
Data from ChEMBL 36 via Core Engine