Assay Detail
Binding
CHEMBL2217161
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of carnitine palmitoyltransferase in rat liver mitochondria assessed as polarographic measurement of oxygen uptake from mitochondria in presence of palmitoyl-CoA and L-carnitine
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Mitochondria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.46 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2216793 | — | — | 1 | 7.52 |
| CHEMBL2216795 | — | — | 1 | 7.52 |
| CHEMBL2216796 | — | — | 1 | 6.52 |
| CHEMBL2216794 | — | — | 1 | 5.75 |
| CHEMBL2216797 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2216793 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2216795 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2216796 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2216794 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2216797 | — | IC50 | = | 10000.0 | nM | 5.00 |