Assay Detail
Binding
CHEMBL2217027
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Maximal inhibition of rat CPT1A
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Carnitine O-palmitoyltransferase 1, muscle isoform (CHEMBL3216) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.52 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2216778 | — | — | 1 | 7.52 |
| CHEMBL2216779 | — | — | 1 | 7.26 |
| CHEMBL2216774 | — | — | 1 | 6.89 |
| CHEMBL2216776 | — | — | 1 | 6.82 |
| CHEMBL2216777 | — | — | 1 | 6.75 |
| CHEMBL1231506 | TEGLICAR | 2.0 | 1 | 5.84 |
| CHEMBL2114397 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2216778 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2216779 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL2216774 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2216776 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2216777 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1231506 | TEGLICAR | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL2114397 | — | IC50 | = | 27300.0 | nM | 4.56 |