Assay Detail
Binding
CHEMBL2217050
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Inhibition of rat CPT2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Carnitine O-palmitoyltransferase 2, mitochondrial (CHEMBL4037) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.17 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1231506 | TEGLICAR | 2.0 | 1 | 6.42 |
| CHEMBL2216779 | — | — | 1 | 5.50 |
| CHEMBL2114397 | — | — | 1 | 5.29 |
| CHEMBL2216777 | — | — | 1 | 4.78 |
| CHEMBL2216780 | — | — | 1 | 4.54 |
| CHEMBL2216774 | — | — | 1 | 4.51 |
| CHEMBL2216771 | — | — | 1 | - |
| CHEMBL129918 | — | — | 1 | - |
| CHEMBL2216775 | — | — | 1 | - |
| CHEMBL2216776 | — | — | 1 | - |
| CHEMBL2216778 | — | — | 1 | - |
| CHEMBL2216772 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1231506 | TEGLICAR | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2216779 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2114397 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL2216777 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL2216780 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL2216774 | — | IC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL2216771 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL129918 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2216775 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2216776 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2216778 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2216772 | — | IC50 | > | 10000.0 | nM | - |