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Assay Detail

CHEMBL2317013

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 cells by Griess reaction based method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type RAW264.7
Confidence 1 — Organism
Curated By Autocuration

Target

RAW264.7 (CHEMBL612557)
Type CELL-LINE
Organism Mus musculus

Publication

Chemical constituents from the fruit of Gardenia jasminoides and their inhibitory effects on nitric oxide production.
Peng K, Yang L, Zhao S, Chen L, Zhao F, Qiu F.
Bioorg Med Chem Lett (2013) 23 : 1127 -1131
PubMed 23305920 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.73 5.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL464792 TRANSCROCETIN 3.0 1 5.22
CHEMBL459016 GENIPIN 3.0 1 4.95
CHEMBL2316923 1 4.54
CHEMBL389621 HYDROCORTISONE 4.0 1 4.19
CHEMBL2311863 1 -
CHEMBL446785 CROCIN 3.0 1 -
CHEMBL2311862 GENAMESIDE C 1 -
CHEMBL2311861 GENAMESIDE D 1 -
CHEMBL2311860 1 -
CHEMBL463844 1 -
CHEMBL504969 GENIPIN GENTIOBIOSIDE 1 -
CHEMBL516850 1 -
CHEMBL462894 GENIPOSIDE 1 -
CHEMBL2316922 JASMINOSIDE T 1 -
CHEMBL2316921 JASMINOSIDE S 1 -
CHEMBL2316920 JASMINOSIDE R 1 -
CHEMBL2316919 1 -
CHEMBL2316918 1 -
CHEMBL2316917 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL464792 TRANSCROCETIN IC50 = 5990.0 nM 5.22
CHEMBL459016 GENIPIN IC50 = 11140.0 nM 4.95
CHEMBL2316923 IC50 = 28680.0 nM 4.54
CHEMBL389621 HYDROCORTISONE IC50 = 64340.0 nM 4.19
CHEMBL2311863 IC50 > 100000.0 nM -
CHEMBL446785 CROCIN IC50 > 100000.0 nM -
CHEMBL2311862 GENAMESIDE C IC50 > 100000.0 nM -
CHEMBL2311861 GENAMESIDE D IC50 > 100000.0 nM -
CHEMBL2311860 IC50 > 100000.0 nM -
CHEMBL463844 IC50 > 100000.0 nM -
CHEMBL504969 GENIPIN GENTIOBIOSIDE IC50 > 100000.0 nM -
CHEMBL516850 IC50 > 100000.0 nM -
CHEMBL462894 GENIPOSIDE IC50 > 100000.0 nM -
CHEMBL2316922 JASMINOSIDE T IC50 > 100000.0 nM -
CHEMBL2316921 JASMINOSIDE S IC50 > 100000.0 nM -
CHEMBL2316920 JASMINOSIDE R IC50 > 100000.0 nM -
CHEMBL2316919 IC50 > 100000.0 nM -
CHEMBL2316918 IC50 > 100000.0 nM -
CHEMBL2316917 IC50 > 100000.0 nM -