Assay Detail
ADMET
CHEMBL2317014
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Cytotoxicity against human HCT116 p53 +/+ and -/- cells after 72 hrs by MTT assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 44 | 5.44 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567420 | — | — | 1 | 6.52 |
| CHEMBL2311899 | — | — | 1 | 6.40 |
| CHEMBL2311898 | — | — | 1 | 6.30 |
| CHEMBL2094455 | — | — | 1 | 5.82 |
| CHEMBL2311865 | — | — | 1 | 5.60 |
| CHEMBL2311878 | — | — | 1 | 5.48 |
| CHEMBL2311895 | — | — | 1 | 5.48 |
| CHEMBL199592 | — | — | 1 | 5.40 |
| CHEMBL2311886 | — | — | 1 | 5.40 |
| CHEMBL2311873 | — | — | 1 | 5.30 |
| CHEMBL2311871 | — | — | 1 | 5.30 |
| CHEMBL2311872 | — | — | 1 | 5.22 |
| CHEMBL2311880 | — | — | 1 | 5.19 |
| CHEMBL2311881 | — | — | 1 | 5.19 |
| CHEMBL2311877 | — | — | 1 | 5.10 |
| CHEMBL569410 | — | — | 1 | 5.05 |
| CHEMBL2311876 | — | — | 1 | 5.00 |
| CHEMBL2311882 | — | — | 1 | 5.00 |
| CHEMBL2311901 | — | — | 1 | 5.00 |
| CHEMBL2311903 | — | — | 1 | 5.00 |
| CHEMBL2311874 | — | — | 1 | - |
| CHEMBL2311869 | — | — | 1 | - |
| CHEMBL2311896 | — | — | 1 | - |
| CHEMBL2311911 | — | — | 1 | - |
| CHEMBL2311910 | — | — | 1 | - |
| CHEMBL2311909 | — | — | 1 | - |
| CHEMBL1976649 | — | — | 1 | - |
| CHEMBL2094513 | — | — | 1 | - |
| CHEMBL2311908 | — | — | 1 | - |
| CHEMBL2311907 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567420 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2311899 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2311898 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2094455 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2311865 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2311878 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2311895 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL199592 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2311886 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2311873 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2311871 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2311872 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2311880 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL2311881 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL2311877 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL569410 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL2311876 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2311903 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2311901 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2311882 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2311887 | — | EC50 | < | 1000.0 | nM | - |
| CHEMBL2311905 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL2311864 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2311868 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2311870 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2311879 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2311890 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3145360 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2311893 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2311894 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2311913 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2311897 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2311904 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2311906 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2311907 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2311908 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2094513 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1976649 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2311909 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2311910 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2311911 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2311896 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2311869 | — | EC50 | < | 1000.0 | nM | - |
| CHEMBL2311874 | — | EC50 | < | 1000.0 | nM | - |