Assay Detail
Binding
CHEMBL2317232
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Inhibition of p38alpha MAP kinase (unknown origin) by ELISA
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 8.36 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2316207 | FS-694 | — | 1 | 9.70 |
| CHEMBL2316490 | — | — | 1 | 9.52 |
| CHEMBL2316466 | — | — | 1 | 9.30 |
| CHEMBL2316491 | — | — | 1 | 9.15 |
| CHEMBL2316485 | — | — | 1 | 9.00 |
| CHEMBL2316486 | — | — | 1 | 9.00 |
| CHEMBL2316489 | — | — | 1 | 9.00 |
| CHEMBL2316494 | — | — | 1 | 9.00 |
| CHEMBL2316497 | — | — | 1 | 9.00 |
| CHEMBL2316206 | — | — | 1 | 9.00 |
| CHEMBL2316472 | — | — | 1 | 8.70 |
| CHEMBL2316483 | — | — | 1 | 8.70 |
| CHEMBL2316488 | — | — | 1 | 8.70 |
| CHEMBL2316474 | — | — | 1 | 8.70 |
| CHEMBL2316479 | — | — | 1 | 8.70 |
| CHEMBL2316201 | — | — | 1 | 8.70 |
| CHEMBL2316205 | — | — | 1 | 8.70 |
| CHEMBL2316492 | — | — | 1 | 8.70 |
| CHEMBL2316470 | — | — | 1 | 8.52 |
| CHEMBL2316473 | — | — | 1 | 8.52 |
| CHEMBL2316476 | — | — | 1 | 8.52 |
| CHEMBL2316477 | — | — | 1 | 8.52 |
| CHEMBL2316481 | — | — | 1 | 8.52 |
| CHEMBL2316202 | — | — | 1 | 8.52 |
| CHEMBL2316208 | — | — | 1 | 8.40 |
| CHEMBL2152944 | Skepinone-L | — | 1 | 8.30 |
| CHEMBL2316475 | — | — | 1 | 8.30 |
| CHEMBL2316478 | — | — | 1 | 8.30 |
| CHEMBL2316197 | — | — | 1 | 8.30 |
| CHEMBL2316196 | — | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2316207 | FS-694 | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL2316490 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2316466 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2316491 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL2316485 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2316486 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2316489 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2316494 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2316497 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2316206 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2316479 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2316483 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2316488 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2316472 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2316474 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2316201 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2316205 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2316492 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2316470 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2316473 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2316476 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2316477 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2316481 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2316202 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2316208 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2316475 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2316478 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2316197 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2152944 | Skepinone-L | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2316196 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2316493 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2316199 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2316203 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2316480 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2316469 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2316195 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2316194 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2316468 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2316496 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2316198 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2316487 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2316482 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2316484 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2316204 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2316467 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2316471 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL2316200 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL2316495 | — | IC50 | = | 98.0 | nM | 7.01 |