Assay Detail
Functional
CHEMBL2317246
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Inhibition of melanogenesis in mouse B16-4A5 cells after 72 hrs by spectrophotometry
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16-4A5 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Alkaloid constituents from flower buds and leaves of sacred lotus (Nelumbo nucifera, Nymphaeaceae) with melanogenesis inhibitory activity in B16 melanoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.75 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2316503 | — | — | 1 | 5.70 |
| CHEMBL2316504 | — | — | 1 | 5.30 |
| CHEMBL281357 | — | — | 1 | 5.23 |
| CHEMBL2316502 | — | — | 1 | 4.88 |
| CHEMBL2316499 | — | — | 1 | 4.84 |
| CHEMBL464529 | NUCIFERINE | — | 1 | 4.80 |
| CHEMBL2316500 | — | — | 1 | 4.71 |
| CHEMBL451722 | — | — | 1 | 4.59 |
| CHEMBL2316498 | — | — | 1 | 4.37 |
| CHEMBL237766 | PRONUCIFERINE | — | 1 | 4.32 |
| CHEMBL1164391 | — | — | 1 | 4.20 |
| CHEMBL2316501 | DEHYDRONUCIFERINE | — | 1 | 4.07 |
| CHEMBL232202 | ARBUTIN | 2.0 | 1 | - |
| CHEMBL389271 | ASIMILOBINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2316503 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2316504 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL281357 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL2316502 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL2316499 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL464529 | NUCIFERINE | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL2316500 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL451722 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL2316498 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL237766 | PRONUCIFERINE | IC50 | = | 47900.0 | nM | 4.32 |
| CHEMBL1164391 | — | IC50 | = | 62900.0 | nM | 4.20 |
| CHEMBL2316501 | DEHYDRONUCIFERINE | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL232202 | ARBUTIN | IC50 | = | 174000.0 | nM | - |
| CHEMBL389271 | ASIMILOBINE | IC50 | > | 100000.0 | nM | - |