Compound Detail
CHEMBL237766
PRONUCIFERINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL237766 |
| Name | PRONUCIFERINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WUYQEGNOQLRQAQ-CQSZACIVSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
311.4
MW (Da)
2.57
ALogP
4
HBA
0
HBD
38.8
PSA (Ų)
0.84
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatitis B virus CHEMBL613497 | IC50 | 4.38 | 4.38 | 42000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.32 | 4.32 | 47900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatitis B virus | IC50 | = | 42000.0 | nM | 4.38 | Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibit... | 17723297 |
| Unchecked | IC50 | = | 47900.0 | nM | 4.32 | Inhibition of melanogenesis in mouse B16-4A5 cells after 72 hrs by spectrophotom... | 23270663 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23270663 | 10.1016/j.bmc.2012.11.038 | Unchecked | 6 |
| 17723297 | 10.1016/j.bmcl.2007.08.027 | Hepatitis B virus | 2 |
| 17723297 | 10.1016/j.bmcl.2007.08.027 | Unchecked | 2 |
| 23270663 | 10.1016/j.bmc.2012.11.038 | ADMET | 2 |
| 17723297 | 10.1016/j.bmcl.2007.08.027 | NON-PROTEIN TARGET | 1 |
| 23642481 | 10.1016/j.bmcl.2013.04.013 | Pancreatic triacylglycerol lipase | 1 |
Data from ChEMBL 36 via Core Engine