Assay Detail
Functional
CHEMBL899338
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Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of surface antigen HBsAg secretion
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepG2 2.2.15 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.74 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1980854 | GLAZIOVINE | 2.0 | 1 | 5.10 |
| CHEMBL237766 | PRONUCIFERINE | — | 1 | 4.38 |
| CHEMBL234980 | HYPSERPANINE A | — | 1 | - |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | - |
| CHEMBL235429 | LAURIFOLINE | — | 1 | - |
| CHEMBL235428 | MAGNOFLORINE | — | 1 | - |
| CHEMBL235213 | HYPSERPANINE B | — | 1 | - |
| CHEMBL235212 | (S)-RETICULINE | — | 1 | - |
| CHEMBL237765 | DAURICUMIDINE | — | 1 | - |
| CHEMBL391835 | DAURICUMINE | — | 1 | - |
| CHEMBL237764 | DECHLOROACUTUMINE | — | 1 | - |
| CHEMBL237548 | ACUTUMIDINE | — | 1 | - |
| CHEMBL391628 | ACUTUMINE | — | 1 | - |
| CHEMBL238413 | PHENOLBETAIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1980854 | GLAZIOVINE | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL237766 | PRONUCIFERINE | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL234980 | HYPSERPANINE A | IC50 | = | 1415000.0 | nM | - |
| CHEMBL141 | LAMIVUDINE | IC50 | = | 11700000.0 | nM | - |
| CHEMBL235429 | LAURIFOLINE | IC50 | > | 3684000.0 | nM | - |
| CHEMBL235428 | MAGNOFLORINE | IC50 | > | 4114000.0 | nM | - |
| CHEMBL235213 | HYPSERPANINE B | IC50 | > | 3615000.0 | nM | - |
| CHEMBL235212 | (S)-RETICULINE | IC50 | = | 2143000.0 | nM | - |
| CHEMBL237765 | DAURICUMIDINE | IC50 | = | 450000.0 | nM | - |
| CHEMBL391835 | DAURICUMINE | IC50 | = | 1312000.0 | nM | - |
| CHEMBL237764 | DECHLOROACUTUMINE | IC50 | > | 2926000.0 | nM | - |
| CHEMBL237548 | ACUTUMIDINE | IC50 | = | 2023000.0 | nM | - |
| CHEMBL391628 | ACUTUMINE | IC50 | > | 2989000.0 | nM | - |
| CHEMBL238413 | PHENOLBETAIN | IC50 | = | 2367000.0 | nM | - |