Assay Detail
Binding
CHEMBL2317360
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 1 hr by microbeta scintillation counting analysis
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 46 | 6.54 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431770 | ISTRADEFYLLINE | 4.0 | 1 | 7.32 |
| CHEMBL2313277 | — | — | 1 | 7.03 |
| CHEMBL2313284 | — | — | 1 | 6.85 |
| CHEMBL39898 | — | — | 1 | 6.77 |
| CHEMBL26138 | — | — | 1 | 6.69 |
| CHEMBL2312987 | — | — | 1 | 6.61 |
| CHEMBL2313297 | — | — | 1 | 6.58 |
| CHEMBL2312988 | — | — | 1 | 6.51 |
| CHEMBL2313294 | — | — | 1 | 6.41 |
| CHEMBL2313293 | — | — | 1 | 6.37 |
| CHEMBL2313296 | — | — | 1 | 6.37 |
| CHEMBL2312991 | — | — | 1 | 6.33 |
| CHEMBL2313298 | — | — | 1 | 6.28 |
| CHEMBL2313274 | — | — | 1 | 6.05 |
| CHEMBL2313283 | — | — | 1 | 5.94 |
| CHEMBL2312982 | — | — | 1 | - |
| CHEMBL2312983 | — | — | 1 | - |
| CHEMBL2312984 | — | — | 1 | - |
| CHEMBL2312985 | — | — | 1 | - |
| CHEMBL2312975 | — | — | 1 | - |
| CHEMBL2313276 | — | — | 1 | - |
| CHEMBL2313287 | — | — | 1 | - |
| CHEMBL2313288 | — | — | 1 | - |
| CHEMBL2312990 | — | — | 1 | - |
| CHEMBL2312989 | — | — | 1 | - |
| CHEMBL2313289 | — | — | 1 | - |
| CHEMBL2313290 | — | — | 1 | - |
| CHEMBL2313291 | — | — | 1 | - |
| CHEMBL2313292 | — | — | 1 | - |
| CHEMBL2313295 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431770 | ISTRADEFYLLINE | Ki | = | 47.4 | nM | 7.32 |
| CHEMBL2313277 | — | Ki | = | 93.9 | nM | 7.03 |
| CHEMBL2313284 | — | Ki | = | 140.8 | nM | 6.85 |
| CHEMBL39898 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL26138 | — | Ki | = | 204.2 | nM | 6.69 |
| CHEMBL2312987 | — | Ki | = | 246.6 | nM | 6.61 |
| CHEMBL2313297 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL2312988 | — | Ki | = | 306.9 | nM | 6.51 |
| CHEMBL2313294 | — | Ki | = | 390.5 | nM | 6.41 |
| CHEMBL2313293 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL2313296 | — | Ki | = | 423.4 | nM | 6.37 |
| CHEMBL2312991 | — | Ki | = | 467.3 | nM | 6.33 |
| CHEMBL2313298 | — | Ki | = | 530.6 | nM | 6.28 |
| CHEMBL2313274 | — | Ki | = | 886.8 | nM | 6.05 |
| CHEMBL2313283 | — | Ki | = | 1144.0 | nM | 5.94 |
| CHEMBL2312980 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2312979 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2312978 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2312977 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2312976 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2313275 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2312974 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2313286 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2313285 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2313282 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2313281 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2313280 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2313279 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2313278 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2312986 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2312981 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2312982 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2312983 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2312984 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2312985 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2312975 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2313276 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2313287 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2313288 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2312990 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2312989 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2313289 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2313290 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2313291 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2313292 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2313295 | — | Ki | > | 10000.0 | nM | - |