Assay Detail
Binding
CHEMBL2317552
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to -40 mV by two electrode voltage clamp analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies of argiotoxins: selective and potent inhibitors of ionotropic glutamate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.11 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2314718 | — | — | 1 | 7.77 |
| CHEMBL2314933 | — | — | 1 | 7.72 |
| CHEMBL2314712 | — | — | 1 | 7.55 |
| CHEMBL2314717 | — | — | 1 | 7.43 |
| CHEMBL2314719 | — | — | 1 | 7.37 |
| CHEMBL2314935 | — | — | 1 | 7.34 |
| CHEMBL2314713 | — | — | 1 | 7.28 |
| CHEMBL2311573 | — | — | 1 | 7.24 |
| CHEMBL2314934 | — | — | 1 | 7.21 |
| CHEMBL2314931 | — | — | 1 | 7.11 |
| CHEMBL2314936 | — | — | 1 | 7.11 |
| CHEMBL1098240 | — | — | 1 | 7.11 |
| CHEMBL2314940 | — | — | 1 | 7.09 |
| CHEMBL2314716 | — | — | 1 | 7.08 |
| CHEMBL2314938 | — | — | 1 | 7.08 |
| CHEMBL2314715 | — | — | 1 | 7.03 |
| CHEMBL2314929 | — | — | 1 | 7.02 |
| CHEMBL2314928 | — | — | 1 | 6.98 |
| CHEMBL2314937 | — | — | 1 | 6.93 |
| CHEMBL2314930 | — | — | 1 | 6.91 |
| CHEMBL2314927 | — | — | 1 | 6.78 |
| CHEMBL2314932 | — | — | 1 | 6.77 |
| CHEMBL2314939 | — | — | 1 | 6.34 |
| CHEMBL2314714 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2314718 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2314933 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2314712 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2314717 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2314719 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2314935 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL2314713 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL2311573 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL2314934 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL2314931 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL2314936 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL1098240 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL2314940 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL2314716 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL2314938 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL2314715 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL2314929 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL2314928 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL2314937 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL2314930 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL2314927 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL2314932 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL2314939 | — | IC50 | = | 454.0 | nM | 6.34 |
| CHEMBL2314714 | — | IC50 | = | 466.0 | nM | 6.33 |