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Compound Detail

CHEMBL2314713

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N=C(N)NCC[C@@H](N)C(=O)NCCCCCCCCNCCCCNC(=O)[C@@H](NC(=O)Cc1ccc(O)cc1O)c1cnc[nH]1

Basic Information

ChEMBL ID CHEMBL2314713
Phase Preclinical
Structure Type MOL
InChI Key FEYRRUYUQQFBJS-KCWPFWIISA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

630.8
MW (Da)
0.36
ALogP
9
HBA
11
HBD
256.4
PSA (Ų)
0.05
QED
2
Ro5 Violations
23
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H50N10O5
MW 630.80
Aromatic Rings 2
Heavy Atoms 45
NP-Likeness 0.02

Activity Summary

IC50 2 meas. best 7.28

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Glutamate receptor 1
CHEMBL3753
IC50 7.28 7.28 52.0 1
Glutamate NMDA receptor; Grin1/Grin2a
CHEMBL2096680
IC50 5.68 5.68 2090.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23320429 10.1021/jm301602d Unchecked 1
23320429 10.1021/jm301602d Glutamate NMDA receptor; Grin1/Grin2a 1
23320429 10.1021/jm301602d Glutamate receptor 1 1

Data from ChEMBL 36 via Core Engine