Assay Detail
Functional
CHEMBL2318041
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Antimelanogenic activity in Xenopus laevis tadpoles assessed as melanophore aggregation by microscopy
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Xenopus laevis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of new N-(arylcyclopropyl)acetamides and N-(arylvinyl)acetamides as conformationally-restricted ligands for melatonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.26 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2314253 | — | — | 1 | 11.00 |
| CHEMBL2314255 | — | — | 1 | 10.46 |
| CHEMBL10878 | AGOMELATINE | 4.0 | 1 | 9.46 |
| CHEMBL2314257 | — | — | 1 | 7.03 |
| CHEMBL2314252 | — | — | 1 | 7.00 |
| CHEMBL2314251 | — | — | 1 | 6.81 |
| CHEMBL229015 | — | — | 1 | 6.07 |
| CHEMBL2314250 | — | — | 1 | - |
| CHEMBL2314259 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2314253 | — | EC50 | = | 0.01 | nM | 11.00 |
| CHEMBL2314255 | — | EC50 | = | 0.035 | nM | 10.46 |
| CHEMBL10878 | AGOMELATINE | EC50 | = | 0.35 | nM | 9.46 |
| CHEMBL2314257 | — | EC50 | = | 93.5 | nM | 7.03 |
| CHEMBL2314252 | — | EC50 | = | 101.0 | nM | 7.00 |
| CHEMBL2314251 | — | EC50 | = | 155.0 | nM | 6.81 |
| CHEMBL229015 | — | EC50 | = | 854.0 | nM | 6.07 |
| CHEMBL2314250 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2314259 | — | EC50 | = | 0.00076 | nM | - |