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Assay Detail

CHEMBL2318568

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against mouse macrophage cell line J774.1 (ATCC TIB-67) for 3 days by Alamar Blue
ChEMBL ↗
94
Total Activities
94
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Cell Type Macrophage
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558) ↗
Type ADMET

Publication

Structure-activity relationships of antitubercular salicylanilides consistent with disruption of the proton gradient via proton shuttling.
Lee IY, Gruber TD, Samuels A, Yun M, Nam B, Kang M, Crowley K, Winterroth B, Boshoff HI, Barry CE.
Bioorg Med Chem (2013) 21 : 114 -126
PubMed 23211970 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 94 5.14 5.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2313121 — — 1 5.77
CHEMBL2313077 — — 1 5.62
CHEMBL2313116 — — 1 5.60
CHEMBL2313080 — — 1 5.58
CHEMBL2088014 — — 1 5.55
CHEMBL2313081 — — 1 5.54
CHEMBL2313114 — — 1 5.51
CHEMBL2179173 — — 1 5.51
CHEMBL2313083 — — 1 5.50
CHEMBL2313098 — — 1 5.50
CHEMBL2313079 — — 1 5.46
CHEMBL2313096 — — 1 5.39
CHEMBL2313099 — — 1 5.37
CHEMBL2313091 — — 1 5.36
CHEMBL2313088 — — 1 5.35
CHEMBL2313089 — — 1 5.35
CHEMBL2313100 — — 1 5.33
CHEMBL2313106 — — 1 5.33
CHEMBL2313082 — — 1 5.32
CHEMBL2313136 — — 1 5.31
CHEMBL2313117 — — 1 5.31
CHEMBL2313110 — — 1 5.29
CHEMBL2312832 — — 1 5.28
CHEMBL2313087 — — 1 5.28
CHEMBL536151 IMD-0354 1.0 1 5.28
CHEMBL2313109 — — 1 5.27
CHEMBL2313115 — — 1 5.27
CHEMBL2313101 — — 1 5.27
CHEMBL2313118 — — 1 5.25
CHEMBL2313090 — — 1 5.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2313121 — IC50 = 1700.0 nM 5.77
CHEMBL2313077 — IC50 = 2400.0 nM 5.62
CHEMBL2313116 — IC50 = 2500.0 nM 5.60
CHEMBL2313080 — IC50 = 2600.0 nM 5.58
CHEMBL2088014 — IC50 = 2800.0 nM 5.55
CHEMBL2313081 — IC50 = 2900.0 nM 5.54
CHEMBL2313114 — IC50 = 3100.0 nM 5.51
CHEMBL2179173 — IC50 = 3100.0 nM 5.51
CHEMBL2313083 — IC50 = 3200.0 nM 5.50
CHEMBL2313098 — IC50 = 3200.0 nM 5.50
CHEMBL2313079 — IC50 = 3500.0 nM 5.46
CHEMBL2313096 — IC50 = 4100.0 nM 5.39
CHEMBL2313099 — IC50 = 4300.0 nM 5.37
CHEMBL2313091 — IC50 = 4400.0 nM 5.36
CHEMBL2313089 — IC50 = 4500.0 nM 5.35
CHEMBL2313088 — IC50 = 4500.0 nM 5.35
CHEMBL2313100 — IC50 = 4700.0 nM 5.33
CHEMBL2313106 — IC50 = 4700.0 nM 5.33
CHEMBL2313082 — IC50 = 4800.0 nM 5.32
CHEMBL2313136 — IC50 = 4900.0 nM 5.31
CHEMBL2313117 — IC50 = 4900.0 nM 5.31
CHEMBL2313110 — IC50 = 5100.0 nM 5.29
CHEMBL2312832 — IC50 = 5300.0 nM 5.28
CHEMBL2313087 — IC50 = 5300.0 nM 5.28
CHEMBL536151 IMD-0354 IC50 = 5200.0 nM 5.28
CHEMBL2313109 — IC50 = 5400.0 nM 5.27
CHEMBL2313101 — IC50 = 5400.0 nM 5.27
CHEMBL2313115 — IC50 = 5400.0 nM 5.27
CHEMBL2313118 — IC50 = 5600.0 nM 5.25
CHEMBL2313090 — IC50 = 5800.0 nM 5.24
CHEMBL2313094 — IC50 = 5800.0 nM 5.24
CHEMBL2179164 — IC50 = 5700.0 nM 5.24
CHEMBL589733 — IC50 = 5900.0 nM 5.23
CHEMBL2313111 — IC50 = 6100.0 nM 5.21
CHEMBL2313107 — IC50 = 6100.0 nM 5.21
CHEMBL2313102 — IC50 = 6200.0 nM 5.21
CHEMBL2179174 — IC50 = 6100.0 nM 5.21
CHEMBL2313093 — IC50 = 6300.0 nM 5.20
CHEMBL2313138 — IC50 = 6600.0 nM 5.18
CHEMBL2313103 — IC50 = 6700.0 nM 5.17
CHEMBL2312823 — IC50 = 7300.0 nM 5.14
CHEMBL2313092 — IC50 = 7700.0 nM 5.11
CHEMBL2313119 — IC50 = 7700.0 nM 5.11
CHEMBL2313128 — IC50 = 7800.0 nM 5.11
CHEMBL2313104 — IC50 = 8000.0 nM 5.10
CHEMBL2312831 — IC50 = 8000.0 nM 5.10
CHEMBL2313137 — IC50 = 8100.0 nM 5.09
CHEMBL2313078 — IC50 = 8500.0 nM 5.07
CHEMBL2313084 — IC50 = 8500.0 nM 5.07
CHEMBL2313108 — IC50 = 9600.0 nM 5.02