Assay Detail
Functional
CHEMBL2318643
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Antiviral activity against HIV infected in human MT4 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Naphthyridinone (NTD) integrase inhibitors: N1 protio and methyl combination substituent effects with C3 amide groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.77 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2316121 | — | — | 1 | 8.40 |
| CHEMBL1256978 | GSK-364735 | 2.0 | 1 | 8.30 |
| CHEMBL2315832 | — | — | 1 | 8.15 |
| CHEMBL2315830 | — | — | 1 | 7.96 |
| CHEMBL2316114 | — | — | 1 | 7.70 |
| CHEMBL2315831 | — | — | 1 | 7.66 |
| CHEMBL2316137 | — | — | 1 | 7.50 |
| CHEMBL2315829 | — | — | 1 | 7.19 |
| CHEMBL2316132 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2316121 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1256978 | GSK-364735 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2315832 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2315830 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2316114 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2315831 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2316137 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2315829 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL2316132 | — | IC50 | = | 80.0 | nM | 7.10 |