Assay Detail
Functional
CHEMBL2318644
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV in presence of 40 mg/mL of purified human serum albumin
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Naphthyridinone (NTD) integrase inhibitors: N1 protio and methyl combination substituent effects with C3 amide groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 7.25 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2315832 | — | — | 1 | 8.15 |
| CHEMBL2315830 | — | — | 1 | 8.05 |
| CHEMBL2316121 | — | — | 1 | 7.96 |
| CHEMBL2315831 | — | — | 1 | 7.92 |
| CHEMBL2315828 | — | — | 1 | 7.82 |
| CHEMBL2316126 | — | — | 1 | 7.82 |
| CHEMBL2316122 | — | — | 1 | 7.82 |
| CHEMBL2316127 | — | — | 1 | 7.75 |
| CHEMBL2316115 | — | — | 1 | 7.72 |
| CHEMBL2316116 | — | — | 1 | 7.72 |
| CHEMBL1256978 | GSK-364735 | 2.0 | 1 | 7.70 |
| CHEMBL2315829 | — | — | 1 | 7.64 |
| CHEMBL2316123 | — | — | 1 | 7.55 |
| CHEMBL2316136 | — | — | 1 | 7.51 |
| CHEMBL2316114 | — | — | 1 | 7.48 |
| CHEMBL2316128 | — | — | 1 | 7.47 |
| CHEMBL492188 | — | — | 1 | 7.46 |
| CHEMBL2316138 | — | — | 1 | 7.43 |
| CHEMBL2316120 | — | — | 1 | 7.40 |
| CHEMBL2316133 | — | — | 1 | 7.39 |
| CHEMBL2316118 | — | — | 1 | 7.39 |
| CHEMBL2316137 | — | — | 1 | 7.38 |
| CHEMBL491347 | — | — | 1 | 7.32 |
| CHEMBL2316111 | — | — | 1 | 7.31 |
| CHEMBL2316132 | — | — | 1 | 7.29 |
| CHEMBL522802 | — | — | 1 | 7.26 |
| CHEMBL2316130 | — | — | 1 | 7.19 |
| CHEMBL2311585 | — | — | 1 | 7.11 |
| CHEMBL2316139 | — | — | 1 | 6.96 |
| CHEMBL2316135 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2315832 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2315830 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2316121 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2315831 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2315828 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2316126 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2316122 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2316127 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2316115 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2316116 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1256978 | GSK-364735 | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2315829 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2316123 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2316136 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2316114 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2316128 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL492188 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2316138 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2316120 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2316133 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2316118 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2316137 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL491347 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL2316111 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2316132 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL522802 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL2316130 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2311585 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL2316139 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2316135 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL2316125 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL521793 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2316112 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2316134 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL2316124 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2316131 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2316129 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2316113 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL2316117 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL491336 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL491538 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL2316119 | — | IC50 | = | 2900.0 | nM | 5.54 |