Assay Detail
Functional
CHEMBL2318908
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Antiproliferative activity against human A16-F10 cells after 48 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A16-F10 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and molecular docking of α,β-unsaturated cyclohexanone analogous of curcumin as potent EGFR inhibitors with antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.24 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 6.70 |
| CHEMBL2316151 | — | — | 1 | 6.15 |
| CHEMBL2316140 | — | — | 1 | 5.61 |
| CHEMBL2316142 | — | — | 1 | 5.49 |
| CHEMBL2316153 | — | — | 1 | 5.48 |
| CHEMBL2316158 | — | — | 1 | 5.45 |
| CHEMBL2316157 | — | — | 1 | 5.33 |
| CHEMBL2316141 | — | — | 1 | 5.29 |
| CHEMBL2316143 | — | — | 1 | 5.25 |
| CHEMBL2316154 | — | — | 1 | 5.23 |
| CHEMBL2316155 | — | — | 1 | 5.15 |
| CHEMBL2316147 | — | — | 1 | 5.12 |
| CHEMBL2316159 | — | — | 1 | 5.11 |
| CHEMBL2316150 | — | — | 1 | 5.01 |
| CHEMBL2316145 | — | — | 1 | 4.97 |
| CHEMBL2316146 | — | — | 1 | 4.91 |
| CHEMBL2316144 | — | — | 1 | 4.91 |
| CHEMBL2316149 | — | — | 1 | 4.91 |
| CHEMBL2316148 | — | — | 1 | 4.74 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.73 |
| CHEMBL2316156 | — | — | 1 | 4.49 |
| CHEMBL2316152 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2316151 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL2316140 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL2316142 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL2316153 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL2316158 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL2316157 | — | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL2316141 | — | IC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL2316143 | — | IC50 | = | 5640.0 | nM | 5.25 |
| CHEMBL2316154 | — | IC50 | = | 5840.0 | nM | 5.23 |
| CHEMBL2316155 | — | IC50 | = | 7040.0 | nM | 5.15 |
| CHEMBL2316147 | — | IC50 | = | 7630.0 | nM | 5.12 |
| CHEMBL2316159 | — | IC50 | = | 7690.0 | nM | 5.11 |
| CHEMBL2316150 | — | IC50 | = | 9720.0 | nM | 5.01 |
| CHEMBL2316145 | — | IC50 | = | 10780.0 | nM | 4.97 |
| CHEMBL2316146 | — | IC50 | = | 12270.0 | nM | 4.91 |
| CHEMBL2316144 | — | IC50 | = | 12420.0 | nM | 4.91 |
| CHEMBL2316149 | — | IC50 | = | 12210.0 | nM | 4.91 |
| CHEMBL2316148 | — | IC50 | = | 18410.0 | nM | 4.74 |
| CHEMBL140 | CURCUMIN | IC50 | = | 18650.0 | nM | 4.73 |
| CHEMBL2316156 | — | IC50 | = | 32650.0 | nM | 4.49 |
| CHEMBL2316152 | — | IC50 | > | 100000.0 | nM | - |