Assay Detail
Binding
CHEMBL2319489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PDGFRalpha using poly[Glu:Tyr] (4:1) peptide substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor alpha (CHEMBL2007) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.59 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2311806 | — | — | 1 | 8.09 |
| CHEMBL2311807 | — | — | 1 | 7.59 |
| CHEMBL2311808 | — | — | 1 | 7.08 |
| CHEMBL255863 | NILOTINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2311806 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL2311807 | — | IC50 | = | 25.96 | nM | 7.59 |
| CHEMBL2311808 | — | IC50 | = | 83.87 | nM | 7.08 |
| CHEMBL255863 | NILOTINIB | IC50 | < | 2.54 | nM | - |