Assay Detail
Binding
CHEMBL2319595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant MAGL using [3H]-2-OG as substrate incubated for 30 mins at room temperature followed by incubation at 37 degC for 10 mins by liquid scintillation assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An unprecedented reversible mode of action of β-lactams for the inhibition of human fatty acid amide hydrolase (hFAAH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.67 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2151432 | — | — | 1 | 5.39 |
| CHEMBL2313948 | — | — | 1 | 4.99 |
| CHEMBL2313951 | — | — | 1 | 4.72 |
| CHEMBL2313941 | — | — | 1 | 4.25 |
| CHEMBL2313949 | — | — | 1 | 4.01 |
| CHEMBL2313947 | — | — | 1 | - |
| CHEMBL2313945 | — | — | 1 | - |
| CHEMBL2313944 | — | — | 1 | - |
| CHEMBL2313943 | — | — | 1 | - |
| CHEMBL2313942 | — | — | 1 | - |
| CHEMBL2313940 | — | — | 1 | - |
| CHEMBL2313952 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2151432 | — | IC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL2313948 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL2313951 | — | IC50 | = | 18960.0 | nM | 4.72 |
| CHEMBL2313941 | — | IC50 | = | 56850.0 | nM | 4.25 |
| CHEMBL2313949 | — | IC50 | = | 98410.0 | nM | 4.01 |
| CHEMBL2313947 | — | IC50 | - | — | - | |
| CHEMBL2313945 | — | IC50 | - | — | - | |
| CHEMBL2313944 | — | IC50 | - | — | - | |
| CHEMBL2313943 | — | IC50 | - | — | - | |
| CHEMBL2313942 | — | IC50 | = | 121700.0 | nM | - |
| CHEMBL2313940 | — | IC50 | - | — | - | |
| CHEMBL2313952 | — | IC50 | - | — | - |