Assay Detail
Binding
CHEMBL2319792
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Inhibition of human recombinant thioredoxin-mediated TG2 activation expressed in T84 cells assessed as blockade of 5-biotinamidopentylamine incorporation after 3 hrs by fluorescence microscopic analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T84 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective inhibition of extracellular thioredoxin by asymmetric disulfides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.32 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2315295 | — | — | 1 | 7.05 |
| CHEMBL2315297 | — | — | 1 | 6.77 |
| CHEMBL2315294 | — | — | 1 | 6.62 |
| CHEMBL2315292 | — | — | 1 | 6.54 |
| CHEMBL2315306 | — | — | 1 | 6.47 |
| CHEMBL2315290 | — | — | 1 | 6.35 |
| CHEMBL2315299 | — | — | 1 | 6.29 |
| CHEMBL2315288 | — | — | 1 | 6.27 |
| CHEMBL406050 | PX-12 | 2.0 | 1 | 5.68 |
| CHEMBL2315305 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2315295 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2315297 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2315294 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2315292 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL2315306 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2315290 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL2315299 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL2315288 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL406050 | PX-12 | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL2315305 | — | IC50 | = | 7310.0 | nM | 5.14 |