Assay Detail
Binding
CHEMBL2320000
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Inhibition of TNIK (unknown origin) by ADP glo luminescent assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
TRAF2 and NCK-interacting protein kinase (CHEMBL4527) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.69 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.85 |
| CHEMBL2312144 | — | — | 1 | 8.52 |
| CHEMBL2312145 | — | — | 1 | 8.40 |
| CHEMBL2312143 | — | — | 1 | 8.30 |
| CHEMBL2312142 | — | — | 1 | 8.22 |
| CHEMBL2312148 | — | — | 1 | 8.10 |
| CHEMBL2312154 | — | — | 1 | 7.96 |
| CHEMBL2312147 | — | — | 1 | 7.96 |
| CHEMBL2312155 | — | — | 1 | 7.70 |
| CHEMBL2312150 | — | — | 1 | 7.39 |
| CHEMBL2312146 | — | — | 1 | 7.26 |
| CHEMBL2312153 | — | — | 1 | 7.20 |
| CHEMBL2312140 | — | — | 1 | 7.19 |
| CHEMBL2312151 | — | — | 1 | 6.93 |
| CHEMBL2312152 | — | — | 1 | 6.56 |
| CHEMBL2312141 | — | — | 1 | 6.54 |
| CHEMBL2312149 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2312144 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2312145 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2312143 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2312142 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2312148 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2312154 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2312147 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2312155 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2312150 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2312146 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL2312153 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL2312140 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2312151 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL2312152 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL2312141 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL2312149 | — | IC50 | > | 1000.0 | nM | - |