Assay Detail
Binding
CHEMBL2320849
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Displacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBN
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Heterobivalent dual-target probe for targeting GRP and Y1 receptors on tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.90 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438945 | HUMAN NEUROPEPTIDE Y | 1.0 | 1 | 8.59 |
| CHEMBL2314836 | — | — | 1 | 8.01 |
| CHEMBL2314835 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438945 | HUMAN NEUROPEPTIDE Y | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL2314836 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL2314835 | — | IC50 | = | 80.0 | nM | 7.10 |