Assay Detail
Functional
CHEMBL2320856
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Antiviral activity against Machupo virus
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mammarenavirus machupoense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.64 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2314859 | — | — | 1 | 8.51 |
| CHEMBL2315146 | — | — | 1 | 7.55 |
| CHEMBL2315140 | — | — | 1 | 7.40 |
| CHEMBL2315147 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2314859 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL2315146 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2315140 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2315147 | — | EC50 | = | 81.0 | nM | 7.09 |