Compound Detail
CHEMBL2315146
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2315146 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JADAFHJMBASJLK-UHFFFAOYSA-N |
4
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
372.5
MW (Da)
4.99
ALogP
5
HBA
1
HBD
52.0
PSA (Ų)
0.50
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 5 meas. best 9.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lassa virus CHEMBL615051 | EC50 | 9.8 | 9.8 | 0.2 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | EC50 | 8.46 | 7.865 | 3.5 | 2 |
| Junin virus CHEMBL4523072 | EC50 | 8.1 | 8.1 | 7.9 | 1 |
| Machupo mammarenavirus CHEMBL4888477 | EC50 | 7.55 | 7.55 | 28.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lassa virus | EC50 | = | 0.16 | nM | 9.8 | Antiviral activity against Lassa virus by pseudo-type antiviral assay | 23265900 |
| NON-PROTEIN TARGET | EC50 | = | 3.5 | nM | 8.46 | Antiviral activity against Guanarito virus | 23265900 |
| Junin virus | EC50 | = | 7.9 | nM | 8.1 | Antiviral activity against Junin virus | 23265900 |
| Machupo mammarenavirus | EC50 | = | 28.0 | nM | 7.55 | Antiviral activity against Machupo virus | 23265900 |
| NON-PROTEIN TARGET | EC50 | = | 54.0 | nM | 7.27 | Antiviral activity against Sabia virus | 23265900 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23265900 | 10.1016/j.bmcl.2012.11.093 | NON-PROTEIN TARGET | 2 |
| 23265900 | 10.1016/j.bmcl.2012.11.093 | Junin virus | 1 |
| 23265900 | 10.1016/j.bmcl.2012.11.093 | Machupo mammarenavirus | 1 |
| 23265900 | 10.1016/j.bmcl.2012.11.093 | Lassa virus | 1 |
Data from ChEMBL 36 via Core Engine