Assay Detail
Binding
CHEMBL2321064
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Inhibition of Laforin (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.46 | 4.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2316907 | — | — | 1 | 4.51 |
| CHEMBL2316902 | — | — | 1 | 4.40 |
| CHEMBL2316906 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2316907 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL2316902 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL2316906 | — | IC50 | > | 30000.0 | nM | - |