Assay Detail
Functional
CHEMBL2321080
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Cytotoxicity against human HCT15 cells after 24 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of amidine and bis amidine derivatives and their evaluation for anti-inflammatory and anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.36 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2316315 | — | — | 1 | 4.92 |
| CHEMBL2316052 | — | — | 1 | 4.60 |
| CHEMBL2316047 | — | — | 1 | 4.45 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.35 |
| CHEMBL123292 | CYCLOHEXIMIDE | 2.0 | 1 | 4.27 |
| CHEMBL88 | CYCLOPHOSPHAMIDE ANHYDROUS | 4.0 | 1 | 4.13 |
| CHEMBL2316042 | — | — | 1 | 4.11 |
| CHEMBL2316050 | — | — | 1 | 4.06 |
| CHEMBL2311587 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2316315 | — | IC50 | = | 11920.0 | nM | 4.92 |
| CHEMBL2316052 | — | IC50 | = | 25090.0 | nM | 4.60 |
| CHEMBL2316047 | — | IC50 | = | 35370.0 | nM | 4.45 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 45010.0 | nM | 4.35 |
| CHEMBL123292 | CYCLOHEXIMIDE | IC50 | = | 54130.0 | nM | 4.27 |
| CHEMBL88 | CYCLOPHOSPHAMIDE ANHYDROUS | IC50 | = | 74320.0 | nM | 4.13 |
| CHEMBL2316042 | — | IC50 | = | 78300.0 | nM | 4.11 |
| CHEMBL2316050 | — | IC50 | = | 87800.0 | nM | 4.06 |
| CHEMBL2311587 | — | IC50 | = | 123760.0 | nM | - |