Assay Detail

CHEMBL2321101

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Binding

Agonist activity at mouse TLR7

ChEMBL ↗

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Target

Toll-like receptor 7 (CHEMBL6085) ↗

Open DB target context

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Toll-like receptor 7 (CHEMBL6085) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Toll-like receptor 7

CHEMBL6085

Anchored from Assay target.

Protein identity Toll-like receptor 7

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Mus musculus
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Toll-like receptor 7 (CHEMBL6085) ↗

Type	SINGLE PROTEIN
Organism	Mus musculus

Publication

Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility.

Nakamura T, Wada H, Kurebayashi H, McInally T, Bonnert R, Isobe Y.
Bioorg Med Chem Lett (2013) 23 : 669 -672
PubMed 23265901 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	6.78	8.34

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2315158	—	—	1	8.34
CHEMBL549344	CPG-52852	2.0	1	5.21

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2315158	—	EC50	=	4.6	nM	8.34
CHEMBL549344	CPG-52852	EC50	=	6224.0	nM	5.21