Assay Detail
Binding
CHEMBL2327342
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TYK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1 uM ATP
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of tricyclic cores for kinase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.43 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2322135 | — | — | 1 | 7.30 |
| CHEMBL2322137 | — | — | 1 | 7.22 |
| CHEMBL2322136 | — | — | 1 | 6.52 |
| CHEMBL2322140 | — | — | 1 | 6.28 |
| CHEMBL2322141 | — | — | 1 | 5.92 |
| CHEMBL2322143 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2322135 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2322137 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2322136 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2322140 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL2322141 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2322143 | — | IC50 | = | 4800.0 | nM | 5.32 |