Assay Detail
Binding
CHEMBL2327434
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Antagonist activity at rat P2X2/3 expressed in HEK-293 cells assessed as inhibition of the intracellular calcium increase after 30 to 40 mins by FLIPR assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Ion channels as therapeutic targets: a drug discovery perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.10 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2324342 | — | — | 1 | 7.13 |
| CHEMBL2011125 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2324342 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL2011125 | — | IC50 | = | 8580.0 | nM | 5.07 |