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Assay Detail

CHEMBL2327778

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human KB-3-1 cells by resazurin reduction assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KB 3-1
Confidence 1 — Organism
Curated By Autocuration

Publication

Conjugates of modified cryptophycins and RGD-peptides enter target cells by endocytosis.
Nahrwold M, Weiß C, Bogner T, Mertink F, Conradi J, Sammet B, Palmisano R, Royo Gracia S, Preuße T, Sewald N.
J Med Chem (2013) 56 : 1853 -1864
PubMed 23387527 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 9.65 10.81

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL316640 CRYPTOPHYCIN 52 1 10.81
CHEMBL2324842 1 10.67
CHEMBL2324841 1 10.28
CHEMBL2324843 1 10.26
CHEMBL2324837 1 10.02
CHEMBL2324847 1 10.00
CHEMBL2324844 1 9.95
CHEMBL2324840 1 9.83
CHEMBL2324846 1 9.60
CHEMBL2324848 1 9.51
CHEMBL2324839 1 9.36
CHEMBL2324845 1 7.94
CHEMBL2324849 1 7.25
CHEMBL2324838 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL316640 CRYPTOPHYCIN 52 IC50 = 0.0155 nM 10.81
CHEMBL2324842 IC50 = 0.0216 nM 10.67
CHEMBL2324841 IC50 = 0.0527 nM 10.28
CHEMBL2324843 IC50 = 0.0546 nM 10.26
CHEMBL2324837 IC50 = 0.0961 nM 10.02
CHEMBL2324847 IC50 = 0.1006 nM 10.00
CHEMBL2324844 IC50 = 0.1119 nM 9.95
CHEMBL2324840 IC50 = 0.1488 nM 9.83
CHEMBL2324846 IC50 = 0.2493 nM 9.60
CHEMBL2324848 IC50 = 0.3124 nM 9.51
CHEMBL2324839 IC50 = 0.4328 nM 9.36
CHEMBL2324845 IC50 = 11.45 nM 7.94
CHEMBL2324849 IC50 = 55.8 nM 7.25
CHEMBL2324838 IC50 = 0.0083 nM -